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| 基因名 | CTSB |
| 英文全称 | cathepsin B |
| 别称 | APP secretase, APPS, cathepsin B, Cathepsin B1, CPSB, CTSB |
| 中文名称 | 组织蛋白酶 B |
| Uniprot | P07858 |
| GeneID | 1508 |
| 交叉反应(推测) | Human Mouse Rat (Bovine Pig Sheep Chicken Monkey Gorilla) |
| 氨基酸大小 | 38kDa |
| 表达氨基酸 | 1-339aa |
| Background | This gene encodes a member of the C1 family of peptidases.Alternative splicing of this gene results in multiple transcript variants.At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products.These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme.This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover.It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP).Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimers disease, the most common cause of dementia.Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors.Multiple pseudogenes of this gene have been identified. |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| 规格 | 10ug 50ug 100ug 1mg |