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| 基因名 | MEK2(MAP2K2) |
| 英文全称 | Mitogen-activated protein kinase 2 |
| 别称 | ERK activator kinase 2, FLJ26075, MAP kinase kinase 2, MAP2K2, MAPK/ERK kinase 2, MAPKK 2, MAPKK2, MEK 2, MEK2, MKK2, PRKMK2 |
| 中文名称 | 丝裂原活化蛋白激酶2 |
| Uniprot | P36507 |
| GeneID | 5605 |
| 交叉反应(推测) | Human Mouse Rat (Dog Chicken) |
| 氨基酸大小 | 44kDa |
| 表达氨基酸 | 1-400aa |
| Background | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family.This kinase is known to play a critical role in mitogen growth factor signal transduction.It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3.The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases.Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome.The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.A pseudogene, which is located on chromosome 7, has been identified for this gene. |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| 规格 | 10ug 50ug 100ug 1mg |