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| 基因名 | PTPN1 |
| 英文全称 | protein tyrosine phosphatase, non-receptor type 1 |
| 别称 | PTP1B;tyrosine-protein phosphatase non-receptor type 1 |
| 中文名称 | 非受体型蛋白酪氨酸磷酸酶1 |
| Uniprot | P18031 |
| GeneID | 5770 |
| 交叉反应(推测) | Human Mouse Rat (Chicken) |
| 氨基酸大小 | 38kDa |
| 表达氨基酸 | 103-435aa |
| Background | The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence.PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues.Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity.PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase.This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.Two transcript variants encoding different isoforms have been found for this gene. |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| 规格 | 10ug 50ug 100ug 1mg |