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| 基因名 | OGG1 |
| 英文全称 | 8-oxoguanine DNA glycosylase |
| 别称 | HMMH; HOGG1; MUTM; OGH1; N-glycosylase/DNA lyase |
| 中文名称 | 8-氧代鸟嘌呤DNA糖基化酶 |
| Uniprot | O15527 |
| GeneID | 4968 |
| 交叉反应(推测) | Human Mouse Rat (Fruit fly) |
| 氨基酸大小 | 39kDa |
| 表达氨基酸 | 1-345aa |
| Background | DNA repair enzyme that incises DNA at 8-oxoG residues.Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA.Has a beta-lyase activity that nicks DNA 3 to the lesion.Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence.Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8.All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization.Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| 规格 | 10ug 50ug 100ug 1mg |