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| 基因名 | P38/MAPK14 |
| 英文全称 | Mitogen-activated protein kinase 14 |
| 别称 | CSBP1, CSBP2, CSPB1, Mxi2, p38, PRKM14, PRKM15 |
| 中文名称 | 丝裂原活化蛋白激酶14 |
| Uniprot | Q16539 |
| GeneID | 1432 |
| 交叉反应(推测) | Human Mouse Rat (Zebrafish Dog Gorilla) |
| 氨基酸大小 | 41kDa |
| 表达氨基酸 | 1-360aa |
| Background | The protein encoded by this gene is a member of the MAP kinase family.MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.This kinase is activated by various environmental stresses and proinflammatory cytokines.The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase.The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| 规格 | 10ug 50ug 100ug 1mg |