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| 基因名 | casp1 |
| 英文全称 | caspase 1, apoptosis-related cysteine peptidase |
| 别称 | CASP 1, CASP1, Caspase 1, Caspase 1/p20/p10, Caspase1, ICE, IL 1 beta converting enzyme, IL 1BC, IL1BC, IL1BCE, Interleukin 1 beta convertase, p10, p20, P45 |
| 中文名称 | 胱天蛋白酶1 |
| Uniprot | P29466 |
| GeneID | 834 |
| 交叉反应(推测) | Human Mouse Rat (Zebrafish Horse Dog Pig Cat) |
| 氨基酸大小 | 45kDa |
| 表达氨基酸 | 1-404aa |
| Background | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family.Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing.This gene has been shown to induce cell apoptosis and may function in various developmental stages.Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease.Alternative splicing results in transcript variants encoding distinct isoforms |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| 规格 | 10ug 50ug 100ug 1mg |