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| 基因名 | CDK4 |
| 英文全称 | cyclin-dependent kinase 4 |
| 别称 | CDK4, Cell division protein kinase 4, CMM3, cyclin dependent kinase 4, PSK J3 |
| 中文名称 | 周期蛋白-依赖性蛋白激酶4 |
| Uniprot | P11802 |
| GeneID | 1019 |
| 交叉反应(推测) | Human Mouse Rat (Bovine Pig) |
| 氨基酸大小 | 34kDa |
| 表达氨基酸 | 1-303aa |
| Background | The protein encoded by this gene is a member of the Ser/Thr protein kinase family.This protein is highly similar to the gene products of S.cerevisiae cdc28 and S.pombe cdc2.It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression.The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a).This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb).Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| 规格 | 10ug 50ug 100ug 1mg |