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| 基因名 | PCSK5 |
| 英文全称 | proprotein convertase subtilisin/kexin type 5 |
| 别称 | hPC6, PC5, PC6, PC6A, PCSK5, Proprotein convertase 5, Proprotein convertase 6, SPC6 |
| 中文名称 | 前蛋白转化酶枯草杆菌蛋白酶/ kexin 型蛋白5 |
| Uniprot | Q92824 |
| GeneID | 5125 |
| 交叉反应(推测) | Human Mouse Rat |
| 氨基酸大小 | 38kDa |
| 表达氨基酸 | 564-913aa |
| Background | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway.The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER.It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired.This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues.It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160.Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| 规格 | 10ug 50ug 100ug 1mg |