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| 基因名 | LIG4 |
| 英文全称 | DNA ligase 4 |
| 别称 | DNA ligase 4, DNA ligase IV, LIG4, ligase IV, DNA, ATP dependent |
| 中文名称 | DNA连接酶4 |
| Uniprot | P49917 |
| GeneID | 3981 |
| 交叉反应(推测) | Human Mouse (Chicken) |
| 氨基酸大小 | 38kDa |
| 表达氨基酸 | 562-911aa |
| Background | The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction.This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ).This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK).Both XRCC4 and DNA-PK are known to be required for NHEJ.The crystal structure of the complex formed by this protein and XRCC4 has been resolved.Defects in this gene are the cause of LIG4 syndrome.Alternatively spliced transcript variants encoding the same protein have been observed. |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| 规格 | 10ug 50ug 100ug 1mg |