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| 基因名 | HMGCR |
| 英文全称 | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase |
| 别称 | HMG CoA reductase, HMGCR |
| 中文名称 | 3-羟基3-甲基戊二酰辅酶A还原酶 |
| Uniprot | P04035 |
| GeneID | 3156 |
| 交叉反应(推测) | Human Mouse Rat (Bovine Fruit fly Pig Rabbit Gorilla) |
| 氨基酸大小 | 38kDa |
| 表达氨基酸 | 486-835aa |
| Background | HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase.Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor.Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.Alternatively spliced transcript variants encoding different isoforms have been found for this gene |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| 规格 | 10ug 50ug 100ug 1mg |