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| 基因名 | ZAP70 |
| 英文全称 | zeta-chain (TCR) associated protein kinase 70kDa |
| 别称 | ZAP70; ADMIO2; IMD48; SRK; STCD; STD; TZK; ZAP-70; tyrosine-protein kinase ZAP-70 |
| 中文名称 | 酪氨酸蛋白激酶ZAP-70 |
| Uniprot | P43403 |
| GeneID | 7535 |
| 交叉反应(推测) | Human Mouse |
| 氨基酸大小 | 36kDa |
| 表达氨基酸 | 1-350aa |
| Background | This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation.This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn.This enzyme is also essential for thymocyte development.Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells.Two transcript variants that encode different isoforms have been found for this gene. |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| 规格 | 10ug 50ug 100ug 1mg |