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| 基因名 | DPYD |
| 英文全称 | dihydropyrimidine dehydrogenase |
| 别称 | DHP; DHPDHASE; DPD; dihydropyrimidine dehydrogenase |
| 中文名称 | 二氢嘧啶脱氢酶[NADP(+)] |
| Uniprot | Q12882 |
| GeneID | 1806 |
| 交叉反应(推测) | Human Mouse Rat (Bovine Zebrafish Pig Gorilla) |
| 氨基酸大小 | 19kDa |
| 表达氨基酸 | 1-173aa |
| Background | The protein encoded by this gene is a pyrimidine catabolic enzyme.Involved in pyrimidine base degradation and catalyzes the reduction of uracil and thymine.Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy.Two transcript variants encoding different isoforms have been found for this gene. |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| 规格 | 10ug 50ug 100ug 1mg |