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| 基因名 | MVK |
| 英文全称 | mevalonate kinase |
| 别称 | LRBP, mevalonate kinase, MK, MVK, MVLK |
| 中文名称 | 甲羟戊酸激酶 |
| Uniprot | Q03426 |
| GeneID | 4598 |
| 交叉反应(推测) | Human Mouse Rat (Bovine) |
| 氨基酸大小 | 42kDa |
| 表达氨基酸 | 1-396aa |
| Background | This gene encodes the peroxisomal enzyme mevalonate kinase.Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis.Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises.Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash.Alternative splicing results in multiple transcript variants. |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| 规格 | 10ug 50ug 100ug 1mg |