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| 基因名 | ABAT |
| 英文全称 | 4-aminobutyrate aminotransferase |
| 别称 | ABAT, GABA aminotransferase, GABA AT, GABA T, GABA transaminase, GABAT, L AIBAT |
| 中文名称 | 4-氨基丁酸酯氨基转移酶 |
| Uniprot | / |
| GeneID | 18 |
| 交叉反应(推测) | / |
| 氨基酸大小 | 13kDa |
| 表达氨基酸 | 1-116aa |
| Background | 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde.The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate.The protein sequence is over 95% similar to the pig protein.GABA is estimated to be present in nearly one-third of human synapses.ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44.The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities.Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| 规格 | 10ug 50ug 100ug 1mg |