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| 基因名 | RFFL |
| 英文全称 | E3 ubiquitin-protein ligase rififylin |
| 别称 | RFFL; CARP-2; CARP2; FRING; RIFIFYLIN; RNF189; RNF34L; E3 ubiquitin-protein ligase rififylin |
| 中文名称 | E3泛素-蛋白连接酶rififylin |
| Uniprot | Q8WZ73 |
| GeneID | 117584 |
| 交叉反应(推测) | Human Mouse Rat |
| 氨基酸大小 | 41kDa |
| 表达氨基酸 | 1-363aa |
| Background | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins.Mediates Lys-48-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex.Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis.Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation.Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation.Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN.May also play a role in endocytic recycling. |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| 规格 | 10ug 50ug 100ug 1mg |