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| 基因名 | PSMD2 |
| 英文全称 | 26S proteasome non-ATPase regulatory subunit 2 |
| 别称 | 26S proteasome subunit p97, P97, Protein 55.11, PSMD2, Rpn1, S2, TRAP2 |
| 中文名称 | 26S蛋白酶体非ATPase调节亚基2 |
| Uniprot | Q13200 |
| GeneID | 5708 |
| 交叉反应(推测) | Human Mouse Rat (Bovine Gorilla) |
| 氨基酸大小 | 38kDa |
| 表达氨基酸 | 559-908aa |
| Background | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator.The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits.The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits.Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.This gene encodes one of the non-ATPase subunits of the 19S regulator lid.In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor.A pseudogene has been identified on chromosome 1.Alternative splicing results in multiple transcript variants of this gene. |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| 规格 | 10ug 50ug 100ug 1mg |