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| 基因名 | CHAC1 |
| 英文全称 | Glutathione-specific gamma-glutamylcyclotransferase 1 |
| 别称 | glutathione-specific gamma-glutamylcyclotransferase 1 |
| 中文名称 | 谷胱甘肽特异性γ-谷氨酰环转移酶1 |
| Uniprot | Q9BUX1 |
| GeneID | 79094 |
| 交叉反应(推测) | Human Mouse Rat (Zebrafish) |
| 氨基酸大小 | 24kDa |
| 表达氨基酸 | 1-222aa |
| Background | Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide.Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623).Glutathione depletion is an important factor for apoptosis initiation and execution.Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178).Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366). |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥85% as determined by reducing SDS-PAGE. |
| 规格 | 10ug 50ug 100ug 1mg |