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微信小章| 产品名称： | FGFR Genetic Alteration Cell Panel |
|---|---|
| 商品货号： | TS139255 |
| Organism： | Homo sapiens, human |
| Components： | ATCC HTB-23 MDA-MB-134-VI ATCC CRL-2066 DMS 114 ATCC CCL-235 SW837 ATCC CCL-246 KG-1 ATCC CCL-247 HCT116 ATCC CRL-5974 SNU-16 ATCC HTB-103 KATO III ATCC CRL-1739 AGS |
| Applications： | This validated panel is composed of 8 select human cancer cell lines carrying various degrees of FGFR1 and FGFR2 amplification, and is useful for FGFR pathway research and for anti-cancer drug discovery. |
| Biosafety Level： | 2 xa0Cells contain Parainfluenza virus type 5
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Comments： | Fibroblast Growth Factor Receptors (FGFRs), are transmembrane tyrosine kinase receptors that induce intracellular tyrosine kinase activity when bound to Fibroblast Growth Factor.xa0 FGFR plays crucial roles in development and cell growth. Upregulation of the FGF/FGFR signaling pathway leads to induction of mitogenic and survival signals, as well as promoting epithelial-mesenchymal transition, invasion and tumor angiogenesis. Amplification or activation of FGFR1 and FGFR2 genes has been linked to several cancer types such as lung cancer, breast cancer and gastric cancer.xa0 The FGFR genetic alteration cell panel (TS139255) is composed of eight selected human tumor cell lines from common cancer types that carry various gene copy number amplification within the FGFR1 or FGFR2 genes. The FGFR1 or FGFR2 status of each cell line has been validated by ATCC. This panel is useful for FGFR pathway research and FGFR inhibitors anti-cancer drug discovery. |
| Product Format： | frozen 8 cryopreserved cell lines |
| Storage Conditions： | liquid nitrogen vapor phase (less than -130°C) only |