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| 产品名称： | Amycolatopsis orientalis (Pittenger and Brigham) Lechevalier et al. |
|---|---|
| 商品货号： | TS141426 |
| Deposited As： | Actinoplanacete sp. |
| Strain Designations： | MA6559 |
| Application： | Produces demethomycin |
| Isolation： | Soil |
| Biosafety Level： | 1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Product Format： | freeze-dried |
| Storage Conditions： | Frozen: -80°C or colder Freeze-Dried: 2°C to 8°C Live Culture: See Propagation Section |
| Disclosure： | This material is cited in a US or other Patent and may not be used to infringe the claims. Depending on the wishes of the Depositor, ATCC may be required to inform the Patent Depositor of the party to which the material was furnished. This material may not have been produced or characterized by ATCC. |
| Preceptrol®： | no |
| Type Strain： | no |
| Comments： | Desmethylation of immunosuppressants FK-506 and FR900520 Transformation of DuP 753 (= MK 954) |
| Medium： | ATCC® Medium 1877: ISP Medium 1 ATCC® Medium 196: Yeast malt extract agar |
| Growth Conditions： | Temperature: 26°C
Atmosphere: Aerobic |
| Name of Depositor： | Merck & Co., Inc. |
| U.S. Patent Number： | |
| References： | Arison BH, et al. Immunosuppressant compound. US Patent 4,981,792 dated Jan 1 1991 Chen TS, et al. Microbial transformation of immunosuppressive compounds. I. Desmethylation of FK506 and immunomycin (FR 900520) by Actinoplanes sp. TS141426. J. Antibiot. 45: 118-123, 1992. PubMed: 1372307 Chen TS, et al. Microbial hydroxylation and glucuronidation of the angiotensin II (AII) receptor antagonist MK 954. J. Antibiot. 46: 131-134, 1993. PubMed: 8436545 |