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| 产品名称： | Streptomyces clavuligerus Higgens and Kastner |
|---|---|
| 商品货号： | TS182311 |
| Strain Designations： | NP1 |
| Application： | Converts externally fed N penicillin into a cephalosporin-type antibiotic Converts penicillin G (benzylpenicillin) into deacetoxycephalosporin G |
| Isolation： | N-methyl-n-nitro-n-nitrosoguanidine (NTG)-derived mutant of ATCC 27064 |
| Biosafety Level： | 1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Product Format： | freeze-dried |
| Storage Conditions： | 2°C to 8°C |
| Preceptrol®： | no |
| Type Strain： | no |
| Comments： | Mutant decreased in cephalosporin production |
| Medium： | ATCC® Medium 196: Yeast malt extract agar ATCC® Medium 1877: ISP Medium 1 |
| Growth Conditions： | Temperature: 28.0°C Atmosphere: Aerobic |
| Name of Depositor： | A Demain |
| Chain of Custody： | ATCC < |
| References： | Mahro B, Demain AL. In vivo conversion of penicillin N into a cephalosporin type antibiotic by a non-producing mutant of Streptomyces clavuligerus. Appl. Microbiol. Biotechnol. 27: 272-275, 1987. Cho H, et al. Elucidation of conditions allowing conversion of penicillin G and other penicillins to deacetoxycephalosporins by resting cells and extracts of Streptomyces clavuligerus NP1. Proc. Natl. Acad. Sci. USA 95: 11544-11548, 1998. PubMed: 9751702 |