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微信小章| 产品名称： | Monoclonal Anti-Human Interferon Beta Protein, Clone A7 (produced in vitro) |
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| 商品货号： | TS185902 |
| Agent： | Monoclonal Anti-Human Interferon Beta Protein, Clone A7 (produced in vitro) |
| Biosafety Level： | 1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Product Format： | frozen |
| Storage Conditions： | -20°C or colder. Repeated freeze-thaw cycles should be avoided. |
| Comments： | Antibody Class: IgG2ak The B cell hybridoma was generated by the fusion of P3X63Ag8.653 myeloma cells with splenocytes from a BALB/c x DBA F1 mouse immunized repeatedly with recombinant human IFN-β protein in adjuvant. The clone A7 antibody is specific for human IFN-β and does not cross-react with IFN-α or IFN-γ. |
| Name of Depositor： | SE Grossberg, Medical College of Wisconsin |
| Source： | Mouse monoclonal antibody prepared against a recombinant form of the human interferon beta protein was purified from clone A7 hybridoma supernatant by protein G affinity chromatography. |
| References： | Redlich PN, SE Grossberg. Analysis of antigenic domains on natural and recombinant human IFN-β by the inhibition of biologic activities with monoclonal antibodies. J. Immunol. 143: 1887-1893, 1989. PubMed: 2476486 Runkel L, et al. Mapping of IFN-β epitopes important for receptor binding and biologic activation: comparison of results achieved using antibody-based methods and alanine substitution mutagenesis. J. Interferon Cytokine Res. 21: 931-941, 2001. PubMed: 11747625 |