微信小陈
微信小章| 产品名称： | Streptomyces hygroscopicus subsp. ascomyceticus |
|---|---|
| 商品货号： | TS191754 |
| Strain Designations： | MA6678 |
| Application： | Produces FK520 methyltransferase 31-O-desmethylimmunomycin - O-methyltransferase Produces prolyl-immunomycin |
| Isolation： | Derived from existing strain |
| Biosafety Level： | 1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Product Format： | freeze-dried |
| Disclosure： | This material is cited in a US or other Patent and may not be used to infringe the claims. Depending on the wishes of the Depositor, ATCC may be required to inform the Patent Depositor of the party to which the material was furnished. This material may not have been produced or characterized by ATCC. |
| Preceptrol®： | no |
| Type Strain： | no |
| Medium： | ATCC® Medium 196: Yeast malt extract agar |
| Growth Conditions： | Temperature: 28.0°C |
| Name of Depositor： | Merck & Co., Inc. |
| U.S. Patent Number： | |
| References： | Shafiee A, et al. Enzymatic synthesis and immunosuppressive activity of novel desmethylated immunomycins (ascomycins). J. Antibiot. 46: 1397-1405, 1993. PubMed: 7693638 Chen SST, et al. Microorganism for producing C-31 desmethyl FR-900520 cyclic hemiketal immunosuppressant agent. US Patent 5,198,358 dated Mar 30 1993 Kaplan L, et al. C-31 methylated FR-900520 cyclic hemiketal immunosuppressant agents. US Patent 5,149,701 dated Sep 22 1992 Byrne KM, et al. A directed biosynthesis for an immunomycin derivative. European Patent 0 478 235 A2 derived from ATCC 14891 |