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微信小章| 产品名称： | BRAF Genetic Alteration Cell Panel |
|---|---|
| 商品货号： | TS191856 |
| Organism： | Homo sapiens, human |
| Components： | ATCC CCL-224 COLO 201 ATCC CCL-238 SW1417 ATCC CRL-11147 A2058 ATCC CRL-2577 RKO ATCC CRL-7898 A101D ATCC HTB-123 DU4475 ATCC HTB-137 Hs 695T ATCC HTB-66 RPMI-7951 |
| Applications： | This validated panel is composed of 8 select human tumor cell lines carrying BRAF mutations, and is useful for BRAF pathway research and for anti-cancer drug discovery. |
| Biosafety Level： | 1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Comments： | BRAF gene is a proto-oncogene encoding the BRAF protein, a serine/threonine kinase of the RAF family that acts downstream of RAS and upstream of MEK in the MAPK/ERK signaling pathway. BRAF mediates cell division, proliferation, and differentiation in response to a host of stimuli.xa0 Mutations in BRAF lead to excessive cellular proliferation and enhanced survival, and often underlie birth defects, and cancers of the thyroid and skin. xa0The BRAF gene is most frequently mutated at codon 600.xa0 BRAF V600E mutation has been found in more than 60% of melanomas, as well as 7-8% of other cancers. The BRAF Genetic Alteration Cell Panel (TS191856) is composed of eight selected human tumor cell lines from various common cancer types that carry BRAF hotspot mutations in codon 600.xa0 The BRAF mutation status of each cell line has been sequenced and validated by ATCC.xa0 This panel is useful for BRAF pathway research and BRAF inhibitors anti-cancer drug discovery. |
| Product Format： | frozen 8 cryopreserved cell lines |
| Storage Conditions： | liquid nitrogen vapor phase (less than -130°C) only |