微信小陈
微信小章| 产品名称： | MET Genetic Alteration Cell Panel |
|---|---|
| 商品货号： | TS213943 |
| Organism： | Homo sapiens, human |
| Components： | ATCC CRL-5973 SNU-5 ATCC HTB-135 Hs 746T ATCC CRL-1585 C32 ATCC CRL-2351 AU565 ATCC CRL-5822 NCI-N87 |
| Applications： | This validated panel is composed of 5 select human tumor cell lines carrying various degrees of MET gene copy number changes, and is useful for RAS pathway research and for anti-cancer drug discovery. |
| Biosafety Level： | 1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Comments： | MET is a member of the tyrosine kinase receptor family, which leads signal transduction from the extracellular matrix into the cytoplasm after binding its ligang, hepatocyte growth factor (HGF).xa0 The MET/HGF signaling pathway has been reported to be aberrantly activated in many human cancers, e.g., gastric cancer. In addition, amplification of MET correlates with poor prognosis, and plays a role in acquired resistance to EGFR inhibitors in patients with EGFR-mutant tumors.xa0xa0 The MET Genetic Alteration Cell Panel (TS213943) is composed of five human tumor cells that carry various degrees of MET gene copy number changes.xa0 The MET status of each cell line has been validated by ATCC.xa0 This panel is useful for studying bio-functions of MET and MET amplification, as well as tyrosine kinase inhibitor anti-cancer drug discovery. |
| Product Format： | frozen 5 cryopreserved cell lines |
| Storage Conditions： | liquid nitrogen vapor phase (less than -130°C) only |