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| 产品名称： | EGFR Genetic Alteration Cell Panel |
|---|---|
| 商品货号： | TS214197 |
| Organism： | Homo sapiens, human |
| Components： | ATCC CRL-2868 HCC827 ATCC CRL-2871 HCC4006 ATCC CCL-231 SW48 ATCC CRL-5908 NCI-H1975 ATCC HTB-132 MDA-MB-468 ATCC HTB-19 BT-20 ATCC HTB-178 NCI-H596 ATCC HTB-177 NCI-H460 ATCC CRL-5928 NCI-H2170 ATCC HTB-20 BT-474 ATCC HTB-27 MDA-MB-361 |
| Applications： | This panel is useful for EGFR pathway research and for anti-cancer drug discovery. |
| Biosafety Level： | 1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Comments： | EGFR/ERBB1/HER1 and ERBB2/EGFR2/HER2 are members of the ErbB super family of receptor tyrosine kinases. These receptors bind multiple EGF family-member ligands to initiate signaling cascades critical for an array of cellular processes, such as proliferation, differentiation, survival, metabolism, and migration. EGFR and ERBB2 are targets of an expanding class of anticancer therapies. The most common mutations associated with sensitivity to EGFR inhibitors include exon 19 deletions and the L858R point mutation.xa0 Conversely, the EGFR T790M Mutation has been linked to drug resistance.xa0xa0
The EGFR genetic alteration cell panel (TS214197) is composed of eleven human tumor cell lines from various common cancer types that carry hotspot mutations or gene copy number amplification within the EGFR or ERBB2 gene. The EGFR and ERBB2 status of each cell line has been sequenced and validated by ATCC. This panel is useful for EGFR pathway research and for anti-cancer drug discovery. |
| Product Format： | frozen |
| Storage Conditions： | LN vapor (less than -130°C) only |